AxiaLIF Clinical Publications

AxiaLIF has more than 95 published clinical studies, including reports of safety and effectiveness, economic benefits, and long term outcomes.

• Akesen B, Wu C, Mehbod AA, Transfeldt EE. Biomechanical evaluation of paracoccygeal transsacral fixation. J Spinal Disord Tech. 2008;21(1):39-44. doi:10.1097/BSD.0b013e3180577242.
• Anand N, Baron EM, Thaiyananthan G, Khalsa K, Goldstein TB. Minimally invasive multilevel percutaneous correction and fusion for adult lumbar degenerative scoliosis: a technique and feasibility study. J Spinal Disord Tech. 2008;21(7):459-467. doi:10.1097/BSD.0b013e318167b06b.
• Anand N, Baron EM, Khandehroo B, Kahwaty S. Long-term 2- to 5-year clinical and functional outcomes of minimally invasive surgery for adult scoliosis. Spine (Phila Pa 1976). 2013;38(18):1566-1575. doi:10.1097/BRS.0b013e31829cb67a.
• Anand N, Baron EM, Khandehroo B. Does minimally invasive transsacral fixation provide anterior column support in adult scoliosis? Clin Orthop Relat Res. 2014;472(6):1769-1775. doi: 10.1007/s11999-0133335-6.
• Anand N, Baron EM, Khandehroo B. Limitations and ceiling effects with circumferential minimally invasive correction techniques for adult scoliosis: analysis of radiological outcomes over a 7-year experience. Neurosurg Focus. 2014;36(5):E14. doi: 10.3171/2014.3.FOCUS13585.
• Anand N, Baron EM. Minimally invasive approaches for the correction of adult spinal deformity. Eur Spine J. 2013;22(2):S232-S241. doi:10.1007/s00586 012-2344-6.
• Anand N, Baron EM. Minimally invasive spine surgery for adult deformity. Tech Orthop. 2011;26(3):181-187.
• Anand N, Baron EM. Minimally invasive treatment of adult scoliosis. Semin Spine Surg.2011;23(1):66-71. doi:10.1053/j.semss.2010.12.007.
• Anand N, Rosemann R, Khalsa B, Baron EM. Mid-term to long-term clinical and functional outcomes of minimally invasive correction and fusion for adults with scoliosis. Neurosurg Focus. 2010;28(3):E6. doi:10.3171/2010.1.FOCUS09278.
• Aryan HE, Newman CB, Gold JJ, Acosta FL, Coover C, Ames C. Percutaneous axial lumbar interbody fusion (axialif) of the L5-S1 segment: Initial clinical and radiographic experience. Minim Invasive Neurosurg. 2008;51(4):225-230. doi:10.1055/s-2008-1080915.
• Bartolozzi P, Sandri A, Cassini M, Ricci M. One-stage posterior decompression-stabilization and trans-sacral interbody fusion after partial reduction for severe L5-S1 spondylolisthesis. Spine (Phila Pa 1976). 2003;28(11):1135-1141.
• Boachie-Adjei O, Anand N, Fleischer G, et al. Letter to the editor: lumbar interbody fusion. J Neurosurg Spine. 2013;18(3):316. doi:10.3171/2012.8.SPINE12776.
• Boachie-Adjei O, Cho W, King AB. Axial lumbar interbody fusion (AxiaLIF) approach for adult scoliosis. Eur Spine J. 2013;22(2):S225-S231. doi:10.1007/s00586-012-2351-7.
• Bohinski RJ, Jain VV, Tobler WD. Presacral retroperitoneal approach to axial lumbar interbody fusion: a new, minimally invasive technique at L5-S1: Clinical outcomes, complications, and fusion rates in 50 patients at 1-year follow up. SAS J. 2010;4(2):54-62. doi:10.1016/j.esas.2010.03.003.
• Botolin S, Agudelo J, Dwyer A, Patel V, Burger E. High rectal injury during trans-1 axial lumbar interbody fusion L5-S1 fixation: a case report. Spine (Phila Pa 1976). 2010.35(4):E144-E148. doi:10.1097/BRS.0b013e3181ca7351.
• Boustani HN, Rohlmann A, Abouezzeddine O, Bergmann G, Zander T. Stiffening effect of a transsacral fusion system for the lumbosacral junction. A probabilistic finite element analysis and sensitivity study. Orthopade. 2011;40(2):162-168. doi:10.1007/s00132-010-1716-z
• Bradley WD, Hisey MS, Verma-Kurvari S, Ohnmeiss DD. Minimally invasive trans-sacral approach to L5-S1 interbody fusion: preliminary results from 1 center and review of the literature. Int J Spine Surg. 2012;6:110-114. doi:10.1016/j.ijsp.2011.12.005.
• Carl AL, Ledet EH, Oliveria C, Pimenta L, Orduz RD, Cragg AH. Percutaneous Axial Lumbar Spine Surgery. From: Perez-Cruet M, Khoo L, Fessler RG (Eds.). An Anatomical Approach to Minimally Invasive Spine Surgery. St. Louis: Quality Medical Publishing. 2006; 653-70.
• Cohen A, Miller LE, Block JE. Minimally invasive presacral approach for revision of an axial lumbar interbody fusion rod due to fall-related lumbosacral instability: a case report. J Med Case Rep. 2011;5:488. doi:10.1186/1752-1947-5-488.
• Cragg A, Carl A, Casteneda F, Dickman C, Guterman L, Oliveira C. New percutaneous access method for minimally invasive anterior lumbosacral surgery. J Spinal Disord Tech. 2004;17(1):21-28.
• DeVine JG, Gloystein D, Singh N. A novel alternative for removal of the axialif (TranS1) in the setting of pseudarthrosis of L5-S1. Spine J. 2009. 9(11):910-915. doi:10.1016/j.spinee.2009.08.459.
• Duan X, Shao Z, Xie K, Wang Z. Research progress of percutaneous 360 degree axial lumbar interbody fusion technique. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2009; 23(8):917-920.
• Durrani A, Mistur R, Shanti N. Presacral approach for L5-S1 fusion. Tech Orthop. 2011;26(3):166-172.
• Eck JC, Hodges S, Humphreys SC. Minimally invasive lumbar spinal fusion. J Am Acad Orthop Surg. 2007;15(6):321-329.
• Erkan S, Wu C, Mehbod AA, Hsu B, Pahl DW, Transfeldt EE. Biomechanical evaluation of a new axialif technique for two-level lumbar fusion. Eur Spine J. 2009;18(6): 807-814. doi: 10.1007/s00586-0090953-5.
• Fleischer GD, Hart D, Ferrara LA, Freeman AL, Avidano EE. Biomechanical effect of transforaminal lumbar interbody fusion and axial interbody threaded rod on range of motion and S1 screw loading in a destabilized L5-S1 spondylolisthesis model. Spine (Phila Pa 1976). 2014;39(2):E82-E88. doi:10.1097/BRS.
• Fleischer GD, Kim YJ, Ferrara LA, Freeman AL, Boachie-Adjei O. Biomechanical analysis of sacral screw strain and range of motion in long posterior spinal fixation constructs: effects of lumbosacral fixation strategies in reducing sacral screw strains. Spine (Phila Pa 1976). 2012; 37(3):E163-E169. doi:10.1097/BRS.0b013e31822ce9a7.
• Fokter SK. Update review and clinical presentation on chronic low back pain treated by axialif. Eur J Orthop Surg Traumatol. 2011;21(1):39-42. doi:10.1007/s00590-010-0656-y.
• Francke E, Fischgrund J. Emerging technologies in spine surgery. Semin Spine Surg. 2008;20(2):154-160. doi:10.1053/j.semss.2008.02.010.
• Garcia-Armengol J, Garcia-Botello S, Martinez-Soriano F, Roig JV, Lledo S. Review of the anatomic concepts in relation to the retrorectal space and endopelvic fascia: Waldeyer’s fascia and the rectorsacral fascia. Colorectal Dis. 2008;10(3):298-302. doi:10.1111/j.14631318.2007.01472.x.
• Gebauer G, Anderson DG. Complications of minimally invasive lumbar spine surgery. Semin Spine Surg. 2011;23(2):114-122. doi:10.1053/j.semss.2010.12.014.
• Gerszten PC, Tobler W, Raley TJ, Miller LE, Block JE, Nasca RJ. Axial presacral lumbar interbody fusion and percutaneous posterior fixation for stabilization of lumbosacral isthmic spondylolisthesis. J Spinal Disord Tech. 2012;25(2):E36-E40. doi:10.1097/BSD.0b013e318233725e.
• Gerszten PC, Tobler WD, Nasca RJ. Retrospective analysis of L5-S1 axial lumbar interbody fusion (AxiaLIF):a comparison with and without the use of recombinant human bone morphogenetic proten-2. Spine J. 2011;11(11):1027-1032. doi:10.1016/j.spinee.2011.10.006.
• Gundanna MI, Miller LE, Block JE. Complications with axial presacral lumbar interbody fusion: A 5-year postmarketing surveillance experience. SAS J. 2011;5(3):90-94. doi:10.1016/j.esas.2011.03.002.
• Guvencer M, Dalbayrak S, Tayefi H, et al. Surgical anatomy of the presacral area. Surg Radiol Anat. 2008;31(4):251-257. doi:10.1007/s00276-008-0435-1.
• Hadjipavlou A, Alpantaki K, Katonis P, Vastardis G, Tzermiadianos M, Bernardos N. Safety and effectiveness of retrorectal presacral approach for lumbosacral axial instrumentation. A clinical study. Acta Orthop Belg. 2013;79(2):222-229.
• He L, Rong L. Research progress of axial lumbar interbody fusion by presacral approach for minimally invasive treatment of lumbosacral degenerative diseases. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2011;25(8):1014-1018.
• Heary RF. Results from interbody fusion. J Neurosurg Spine. 2012;17(3):185-186. doi:10.3171/2012.3.SPINE12206.
• Hire JM, Jacobs JM, Bundy JV, DeVine JG. A modified bohlman technique using a novel implant for treatment of high-grade spondylolisthesis. J Neurosurg Spine. 2015;22(1):80-83. doi: 10.3171/2014.10.SPINE14138.
• Hofstetter CP, James AR, Härtl R. Revision strategies for AxiaLIF. Neurosurg Focus. 2011;31(4):E17. doi:10.3171/2011.8.FOCUS11139.
• Hussain NS, Perez-Cruet MJ. Complication management with minimally invasive spine procedures. Neurosurg Focus. 2011;31(4):E2. doi:10.3171/2011.8.FOCUS11165.
• Issack PS, Boachie-Adjei O. Axial lumbosacral interbody fusion appears safe as a method to obtain lumbosacral arthrodesis distal to long fusion HSS J. 2012;8(2): 116-121. doi:10.1007/s11420-0119227-y.
• Ledet EH, Carl AL, Cragg A. Novel lumbosacral axial fixation techniques. Expert Rev Med Devices. 2006; 3(3):327-334.
• Ledet EH, Tymeson MP, Salerno S, Carl AL, Cragg A. Biomechanical evaluation of a novel lumbosacral axial fixation device. J Biomech Eng. 2005;127(6):929-933. doi:10.1115/1.2049334.
• Li X, Zhang Y, Hou Z, Wu T, Ding Z. The relevant anatomy of the approach for axial lumbar interbody fusion. Spine (Phila Pa 1976). 2012;37(4):266-271. doi:10.1097/BRS.0b013e31821b8f6d.
• Lieberman IH, Cragg A. Paracoccygeal transsacral access to the lumbosacral junction for interbody fusion and stabilization. Minimally Invasive Spine Surgery. 2009;87-92.
• Lindley EM, McCullough MA, Burger EL, Brown CW, Patel VV. Complications of axial lumbar interbody fusion. J Neurosurg Spine. 2011;15(3):273-279. doi:10.3171/2011.3.SPINE10373.
• Liu BF, Zhang LG, Liu YB, et al. Is the transsacral axial interbody fusion a candidate surgical approach for fusing both L5/S1 and L4/5. Chin Med J (Engl). 2011;124(2):215-217.
• Louwerens JK, Groot D, Van Duijvenbode DC, Spruit M. Alternative surgical strategy for AxiaLIF pseudarthrosis: a series of three case reports. Evid Based Spine Care J. 2013;4(2):143-148. doi: 10.1055/s-0033-1357357.
• Luther N, Tomasino A, Parikh K, Härtl R. Neuronavigation in the minimally invasive presacral approach for lumbosacral fusion. Minim Invasive Neurosurg. 2009;52(4):196-200. doi:10.1055/s-0029-1239504.
• Manjila S, Singer J, Knudson K, Tomac AC, Hart DJ. Minimally invasive presacral retrieval of a failed AxiaLIF rod implant: technical note and illustrative cases. Spine J. 2012;12(10):940-948. doi:10.1016/j.spinee.2012.10.026.
• Marawar S, Ordway N, Jung J, Sun M. Changes in neuroforaminal height with 2 level axial presacral lumbar interbody fusion at L4-S1. Int J Spine Surg. 2014;1(8).
• Marchi L, Oliveira L, Coutinho E, Pimenta L. Results and complications after 2-level axial lumbar interbody fusion with a minimum 2-year follow-up. J Neurosurg Spine. 2012;17(3):187-192. doi:10.3171/2012.6.SPINE11915.
• Marotta N, Cosar M, Pimenta L, Khoo LT. A novel minimally invasive presacral approach and instrumentation technique for anterior L5-S1 intervertebral discectomy and fusion: technical note and case presentations. Neurosurg Focus. 2006. 20(1):E9.
• Melgar MA, Tobler WD, Ernst RJ, et al. Segmental and global lordosis changes with two-level axial lumbar interbody fusion and posterior instrumentation. Int J Spine Surg. 2014;1(8). doi:10.14444/1010.
• Mummaneni PV, Tu TH, Ziewacz JE, Akinbo OC, Deviren V, Mundis GM. The role of minimally invasive techniques in the treatment of adult spinal deformity. Neurosurg Clin N Am. 2013;24(2):231-248. doi:10.1016/j.nec.2012.12.004.
• Nagineni VV, James AR, Alimi M, et al. Silicate-substituted calcium phosphate ceramic bone graft replacement for spinal fusion procedures. Spine (Phila Pa 1976). 2012;37(20):E1264-E1272.
• Nasca RJ. Newer lumbar interbody fusion techniques. J Surg Orthop Adv. 2013; 22(2):113-117.
• Oppenheimer JH, DeCastro I, McDonnell DE. Minimally invasive spine technology and minimally invasive spine surgery: a historical review. Neurosurg Focus. 2009.27(3):E9. doi:10.3171/2009.7.FOCUS09121.
• Osman SG. Endoscopic transforaminal decompression, interbody fusion, and percutaneous pedicle screw implantation of the lumbar spine: a case series report. Int J Spine Surg. 2012;1(6):157-166. doi:10.1016/j.ijsp.2012.04.001.
• Ozgur B. Combined XLIF and AxiaLIF techniques for minimally-invasive surgical access. Internet J Minim Invasive Spinal Tech. 2008;2(3).
• Ozgur B. Minimally invasive trans-sacral approach to the lumbosacral spine. Internet J Minim Invasive Spinal Tech. 2009;3(4).
• Patil SS, Lindley EM, Patel VV, Burger EL. Clinical and radiological outcomes of axial lumbar interbody fusion. Orthopedics. 2010;33(12):883. doi:10.3928/01477447-20101021-05.
• Pimenta L, Pesantez C, Oliveira L, Schaffo T, Perez-Cruet M, Coutinho E, Tobler W. Presacral axial lumbar interbody fusion. In: Minimally invasive spine fusion: Techniques and operative nuances. 23:444
• Rapp SM, Miller LE, Block JE. AxiaLIF system: minimally invasive device for presacral lumbar interbody spinal fusion. Med Devices (Auckl). 2011;4:125-131. doi:2147/MDER.S23606.
• Rivadeneira DE, Lee SW, Ng PC, Härtl R, Hofstetter CP. Best practices in prevention, detection, and treatment of colorectal perforations during axial lumbar interbody fusion. Tech Orthop. 2012;27(3):209-217. doi:10.1097/BTO.0b013e318263f3db.
• Schoenfeld AJ. Minimally invasive lumbar fusion. Semin Spine Surg. 2011;23(4):235-241. doi:10.1053/j.semss.2011.05.004.
• Schroeder GD, Kepler CK, Vaccaro AR. Axial interbody arthrodesis of the L5-S1 segment: a systematic review of the literature. J Neurosurg Spine. 2015;23(3):314-319. doi:10.3171/2015.1.SPINE14900.
• Shen FH, Samartzis D, Khanna AJ, Anderson D. Minimally invasive techniques for lumbar interbody fusions. Orthop Clin North Am. 2007;38(3):373-386. doi:10.1016/j.ocl.2007.04.002.
• Siegel G, Patel N, Ramakirishnan R. Rectocutaneous fistula and nonunion after TranS1 axial lumbar interbody fusion L5-S1 fixation: case report. J Neurosurg Spine. 2013;19(2):197-200. doi:10.3171/2013.5.SPINE11523
• Smith WD, Youssef JA, Christian G, Serrano S, Hyde JA. Lumbarized sacrum as a relative contraindication for lateral transpsoas interbody fusion at L5-6. J Spinal Disord Tech. 2012;25(5):285-291. doi:10.1097/BSD.0b013e31821e262f.
• Stippler M, Turka M, Gerszten P. Outcomes after percutaneous TranS1 axiaLIF L5-S1 interbody fusion for intractable lower back pain. Int J Spine Surg. 2007;5(1).
• Tender GC, Miller LE, Block JE. Percutaneous pedicle screw reduction and axial presacral lumbar interbody fusion for treatment of lumbosacral spondylolisthesis: a case series. J Med Case Rep. 2011;12(5):454. doi:10.1186/1752-1947-5-454.
• Tobler W. Minimally invasive spine, tranS1 sacral. In: Core Techniques in Operative Neurosurgery. 2011;2(8):576-587.
• Tobler WD, Ferrara LA. The presacral retroperitoneal approach for axial lumbar interbody fusion: a prospective study of clinical outcomes, complications and fusion rates at a follow-up of two years in 26 patients. J Bone Joint Surg Br. 2011;93(7):955-960. doi:10.1302/0301-620X.93B7.25188.
• Tobler WD, Gerszten PC, Bradley WD, Raley TJ, Nasca RJ, Block JE. Minimally invasive axial presacral L5-S1 interbody fusion: two year clinical and radiographic outcomes. Spine (Phila Pa 1976). 2011;36(20):E1296-E1301. doi:10.1097/BRS.0b013e31821b3e37.
• Tobler WD, Melgar MA, Raley TJ, Anand N, Miller LE, Nasca RJ. Clinical and radiographic outcomes with L4-S1 axial lumbar interbody fusion (AxiaLIF) and posterior instrumentation: a multicenter study. Med Devices (Auckl). 2013;18(6):155-161. doi: 10.2147/MDER.S48442.
• Uribe JS, Deukmedjian AR, Mummaneni PV, et al. Complications in adult spinal deformity surgery: an analysis of minimally invasive, hybrid, and open surgical techniques. Neurosurg Focus. 2014;36(5):E15. doi: 10.3171/2014.3.FOCUS13534.
• Wang MY. Minimally invasive methods of spinal fixation. Semin Spine Surg. 2011;23(1):34-39. doi:10.1053/j.semss.2010.12.003.
• Whang PG, Sasso RC, Patel VV, Ali RM, Fischgrund JS. Comparison of axial and anterior interbody fusions of the L5-S1 segment: a retrospective cohort analysis. J Spinal Disord Tech. 2013;26(8):437-443. doi:10.1097/BSD.0b013e318292aad7.
• Wieslander CK, Rahn DD, McIntire DD, et al. Vascular anatomy of the presacral space in unembalmed female cadavers. Am J Obstet Gynecol. 2006;195(6):1736-1741.
• Wilson JR, Timothy J, Rao A, Sagar PM. Retrieval of a migrated AxiaLIF lumbosacral screw using fluoroscopic guidance with simultaneous real time sigmoidoscopy: technical report. Spine (Phila Pa 1976). 2013;38(20):E1285-1287. doi:10.1097/BRS.0b013e31829fef1b.
• Wu TL, Xu HG, Zhang Y, Wang H, Jin S, Wang LT. Relevant imaging and anatomical measurements of presacral space for axial lumbosacral interbody fusion. Zhonghua Yi Xue Za Zhi. 2010; 90(1):19-23.
• Xu HG, Yang XM, Wu TL, Wang H, Chen XW, Wang LT, Liu P. Finite element analysis of the screw in percutaneous axial lumbosacral interbody fusion. Orthop Surg. 2010;2(3):207-210.
• Yamashita T, Steinmetz MP, Lieberman IH, Modic MT, Mroz TE. The utility of repeated postoperative radiographs after lumbar instrumented fusion for degenerative lumbar spine. Spine (Phila Pa 1976). 2011;36(23):1955-1960. doi: 10.1097/BRS.0b013e31820125b5.
• Yan N, Zhang HL, Gu GF, et al. Magnetic resonance imaging analysis of surgical trans-sacral axial L5/S1 interbody fusion. Chin Med J (Engl). 2011;124(18):2911–2914.
• Yuan PS, Day TF, Albert TJ, et al. Anatomy of the percutaneous presacral space for a novel fusion technique. J Spinal Disord Tech. 2006;19(4):237-241.
• Zeilstra DJ, Miller LE, Block JE. Axial lumbar interbody fusion: a 6-year single center experience. Clin Interv Aging. 2013;8:1063-1069. doi:10.2147/CIA.S49802.